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Garcinia cambogia is hot. Nearly one million Americans each month Google this supposed weight-loss supplement. They’re looking for reviews on garcinia cambogia’s effectiveness, what kind of unwanted effects it causes, and where they may buy it. My mom recently obtained a bottle from the pills at Costco because she saw a segment about which garcinia cambogia to buy on a Tv series.

Manufacturers report that garcinia cambogia boosts weight loss by, among other things, “slowing the body’s power to absorb fat,” “replacing fat with toned muscles,” and in many cases boosting your mood and suppressing “the drive to react to stressful situations with food.” How, you may ask? It’s mostly pinned on hydroxycitric acid (HCA), a substance located in garcinia cambogia that appears to inhibit an enzyme called citrate lyase and inhibits fatty acid metabolism.

“HCA does achieve that-but also in a petri dish,” says Steven Heymsfield, M.D., the first kind head of your Pennington Biomedical Research Center in Baton Rouge, La. “Converting that to actual weight reduction in humans would take one thousand steps beyond that,” he says.

Back 1998, Heymsfield published the first randomized controlled trial on the strength of garcinia cambogia, in the Journal of the American Medical Association. He found no weight-loss benefits. Heymsfield, who consistently study the main topic of weight-loss supplements at Pennington, says that about a dozen negative reports have since been published about garcinia cambogia. But containing not stopped marketers from the supplement, he says, from “weaving a story with obscure facts. Maybe each fragment has some validity, but when you wind it together it makes no sense whatsoever.”

His original study, conducted by Columbia University’s Obesity Research Center, looked at 135 overweight individuals age 18 to 65; about half received garcinia cambogia and the other half a placebo three times each day before meals. Both groups ate a high-fiber diet and returned for evaluation every 14 days. After the 12-week trial, there are no important variations in weight reduction between the two groups.

Overview of 12 trials involving forskolin results published within the Journal of Obesity in 2011 stumbled on exactly the same conclusion. Another study by researchers at Victoria University in Melbourne, Australia, and published in 2013 within the journal Complementary Therapies in Medicine learned that overall the evidence for garcinia cambogia was “not compelling.”

Regarding garcinia cambogia’s unwanted effects, controlled studies and animal studies have found not many, although Heymsfield says, “I don’t think it’s totally safe.”

In 2009 the foodstuff and Drug Administration warned consumers about Hydroxycut, something line containing garcinia cambogia and many other ingredients, based on serious reports of health conditions, including jaundice, elevated liver enzymes, liver damage requiring a transplant, and something death from liver failure. The FDA stated it be11yfat struggling to determine exactly which ingredients were related to the liver injuries. (Hydroxycut’s manufacturer, Iovate Health Sciences, withdrew the merchandise, while it has since returned a reformulated product for the market containing no garcinia cambogia.)

“Being obese is difficult because only several of it is related to self-control,” Heymsfield says. “And it’s challenging to lose weight within our environment. Just preventing further an increase in weight is definitely an accomplishment for many people.” The biggest downside to forskolin fat burner, Heymsfield says, besides being a total waste of money, is that it distracts people from concentrating on the most important things when it comes to weight reduction: boosting your activity level and eating a healthier diet.